- Also known as
- 5-amino-1-methylquinolinium · 5A1MQ · 5-AMQ · 5MQ · NNMT inhibitor
- Class
- Small-molecule nicotinamide N-methyltransferase (NNMT) inhibitor
- Form
- Lyophilised powder in 50 mg vials
- Sizes
- 50 mg
- Storage, dry
- −20 °C, dry and dark
- Storage, mixed
- 2–8 °C, use within 28 days of mixing (as generally reported for reconstituted peptides)
- BAC water per size
- 50 mg: 5 mL
What is 5-Amino-1MQ?
The literature describes 5-Amino-1MQ as small-molecule nicotinamide N-methyltransferase (NNMT) inhibitor. Published work on it is in rat, mouse and cell culture. The name covers the same material written several ways in the literature, including 5-amino-1-methylquinolinium, 5A1MQ and 5-AMQ. Its sequence is recorded as Not a peptide: a quinolinium small molecule, detected in LC-MS/MS at m/z 159.1 (Awosemo et al. 2021). No human study of 5-Amino-1MQ has been published, so nothing on this page describes what it does in a person. Borealis Peptides supplies it as lyophilised powder in 50 mg vials for in-vitro laboratory research. Nothing here is a medicine; it is not for human or veterinary use.
What the research shows
| Study | Model | Dose used | Duration | Finding |
|---|---|---|---|---|
| Babula JJ et al.2024 · Diabetes Obes Metab · PMID 39161060 | Mouse, diet-induced obese (DIO) mice; plus pharmacokinetics in age- and strain-matched mice | Not stated in the abstract (once daily); PK after intravenous, oral and subcutaneous dosing | 28 days | 5A1MQ dose-dependently limited body weight and fat mass gains, improved oral glucose tolerance and insulin sensitivity, and reduced hepatic steatosis and liver triglycerides. ALT, AST and ketone bodies were normalised, and subcutaneous dosing distributed it to adipose, muscle and liver. |
| Neelakantan H et al.2018 · Biochem Pharmacol · PMID 29155147 | Cell culture (adipocytes, Caco-2 permeability) and mouse, diet-induced obese mice; methylquinolinium NNMT inhibitor series (the abstract does not name the compound used in mice) | Not stated in the abstract | Not stated in the abstract | The inhibitors reduced 1-MNA, raised NAD+ and SAM and suppressed lipogenesis in adipocytes. In obese mice, a potent inhibitor reduced body weight, white fat mass, adipocyte size and plasma cholesterol without changing food intake or producing observable adverse effects. |
| Neelakantan H et al.2019 · Biochem Pharmacol · PMID 30753815 | Mouse, 24-month-old mice with barium chloride tibialis anterior injury, plus C2C12 myoblasts; NNMT inhibitor from the same group (the abstract does not name the compound) | 5 or 10 mg/kg NNMTi, or saline control | 1 week or 3 weeks after injury | Muscle stem cell proliferation and fusion increased, myofiber cross-sectional area was nearly 2-fold greater and peak torque of the injured muscle was about 70% higher than in controls. |
| Dimet-Wiley A et al.2022 · Sci Rep · PMID 35013352 | Mouse, diet-induced obese mice switched to a low-fat diet | Not stated in the abstract (5-amino-1-methylquinolinium with low-fat diet) | Not stated in the abstract | Mice given 5-amino-1MQ plus the low-fat diet had a distinct caecal microbiome, with less Erysipelatoclostridium and more Lactobacillus than vehicle-treated mice on the same diet. The abstract notes the combination normalised adiposity and weight to those of lean mice. |
| Yang M et al.2024 · J Immunother Cancer · PMID 39067875 | Mouse, urothelial bladder cancer models; plus human bladder cancer tissue cohorts (association data) | Not stated in the abstract (5-amino-1-methylquinolinium iodide) | Not stated in the abstract | Targeting NNMT with 5-amino-1-methylquinolinium iodide reduced tumour growth and enhanced the apoptotic effects of an anti-PD-L1 antibody in mouse models. The human data were associations between NNMT in tumour fibroblasts and non-response to immunotherapy. |
| Awosemo O et al.2021 · J Pharm Biomed Anal · PMID 34304009 | Rat, pharmacokinetic study with a validated LC-MS/MS assay | Not stated in the abstract (intravenous and oral) | Not stated in the abstract | 5-AMQ reached substantial plasma exposure by both routes, with a mean maximum plasma concentration of 2252 ng/mL after oral dosing. The first terminal half-life reported was 3.80 ± 1.10 h; the stored abstract is cut off before the second value. |
| Akar S et al.2021 · J Obstet Gynaecol · PMID 33645410 | Cell culture (HeLa cervical cancer cells, HEK-293 cells) | 0.1–500 µM 5MQ (5-amino-1-methylquinolinium) | Not stated in the abstract | 5MQ inhibited HeLa cell proliferation in a concentration- and time-dependent manner, with signs of apoptosis and lower phospho-Akt and SIRT1 protein. HEK-293 cell proliferation was not apparently affected. |
What these studies don't show: These studies were done in animals and cells. The human question is open, because no human study exists. Dose, route and timing in an animal model do not transfer to people, and nothing here should be read as if they did. A certificate of analysis answers what the material is, not what it does.
Every study links to its PubMed record. See all 5-Amino-1MQ studies in the research library →
5-Amino-1MQ price in Canada: 50mg vial
Buy 5-Amino-1MQ in Canada in a 50mg vial and a starter kit. Prices are in Canadian dollars, you pay by Interac e-Transfer or bank transfer, and orders are shipped from Canadian stock.
| Size | Price | Per mg |
|---|---|---|
| 50 mg | $62.00 | $1.24/mg |
Starter kit
Is 5-Amino-1MQ available in Canada?
5-Amino-1MQ has no Drug Identification Number, which is how Health Canada marks a drug it has authorized. It has had no safety, efficacy or quality review from Health Canada. Borealis Peptides supplies it for in-vitro laboratory research only, not for human or veterinary use. How Health Canada treats research peptides →
Side effects reported in studies
The studies cited below report what they observed on tolerability, and those statements are reproduced as written. Animal and cell work of this size does not establish a safety profile. Read more →
Doses used in studies
5-Amino-1MQ FAQ
What is 5-Amino-1MQ?
Chemically, 5-Amino-1MQ is classed as small-molecule nicotinamide N-methyltransferase (NNMT) inhibitor. The published work on it is in rat, mouse and cell culture. Borealis Peptides supplies it as lyophilised powder in 50 mg vials for in-vitro laboratory research. Nothing here is a medicine; it is not for human or veterinary use. Every reference here is listed with the model it ran in and the finding as published.
Where can I buy 5-Amino-1MQ in Canada?
Direct from Borealis Peptides, held in Canadian stock so nothing crosses a border on its way to you. Stocked in 50 mg vials. Purity is confirmed by HPLC batch by batch, and we supply for laboratory research only. HPLC runs on each batch, and the certificate you receive refers to the batch you were sent.
Is 5-Amino-1MQ legal in Canada?
5-Amino-1MQ has no Drug Identification Number, which is how Health Canada marks a drug it has authorized. It has had no safety, efficacy or quality review from Health Canada. Borealis Peptides supplies it for in-vitro laboratory research only, not for human or veterinary use. Health Canada has said that "Research Use Only" labelling does not make a product legal to use in a person, so we treat it as a description of what the material is supplied for rather than a permission.
How much 5-Amino-1MQ should I use?
There is none to give. Nothing on this site is a protocol, a schedule or a reconstitution volume. The amounts in the cited studies belong to those studies and to the models they ran in, and they are listed so the evidence can be weighed rather than taken on trust.
Has 5-Amino-1MQ been tested in people?
No. The 7 studies cited here used animals or cell culture. There is no published human study of 5-Amino-1MQ, so there is no evidence about what it does in a person, and this page makes no claim about that. The animal work is listed with its model so it can be read for what it is.
What storage does 5-Amino-1MQ need?
Unopened, keep it at −20 °C in the dark. After mixing, storage is 2–8 °C. Ambient transit does not harm the dry powder, which should be refrigerated once received. Keeping it dark and at a steady temperature matters more than how fast it arrived.
How is the purity of 5-Amino-1MQ confirmed?
Identity and purity are confirmed by HPLC for each batch, not once per product. The certificate names the batch it belongs to, and that batch number is on the vial, so a result can be traced back to the exact material that produced it. Ask with your order number and we send it.
How does 5-Amino-1MQ compare with NAD+ and MOTS-C?
They are not interchangeable, and this page makes no claim that one is preferable. NAD+ and MOTS-C have 8 cited studies and 7 cited studies on their page against 7 here. The useful comparison is between the two study tables and the models behind them.
Compare with
Related compounds
SLU-PP-332
Synthetic pan-ERR (ERRα/β/γ) agonist, small molecule
Add 2 more to save 4%
AOD-9604
Modified C-terminal fragment of human growth hormone
Add 2 more to save 4%