- Also known as
- Selank peptide · tuftsin analogue · Thr-Lys-Pro-Arg-Pro-Gly-Pro · TKPRPGP
- Class
- Synthetic tuftsin analogue (heptapeptide)
- Form
- Lyophilised powder in 10 mg vials and a ready-mixed nasal spray
- Sizes
- 10 mg
- Storage, dry
- −20 °C, dry and dark
- Storage, mixed
- 2–8 °C, use within 28 days of mixing (as generally reported for reconstituted peptides)
- BAC water per size
- 10 mg: 2 mL
What is Selank?
The literature describes Selank as synthetic tuftsin analogue (heptapeptide). Published work on it is in rat, human and mouse. The name covers the same material written several ways in the literature, including Selank peptide, tuftsin analogue and Thr-Lys-Pro-Arg-Pro-Gly-Pro. Its sequence is recorded as Thr-Lys-Pro-Arg-Pro-Gly-Pro: tuftsin plus a C-terminal Pro-Gly-Pro. 3 of the 8 studies listed below are controlled trials in people. It appears in the literature as Selank peptide, tuftsin analogue and Thr-Lys-Pro-Arg-Pro-Gly-Pro. Borealis Peptides supplies it as lyophilised powder in 10 mg vials and a ready-mixed nasal spray for in-vitro laboratory research. It is not a medicine and is not for use in humans or animals.
What the research shows
| Study | Model | Dose used | Duration | Finding |
|---|---|---|---|---|
| Zozulia AA et al.2008 · Zh Nevrol Psikhiatr Im S S Korsakova · PMID 18454096 | Human, randomised controlled trial, generalised anxiety disorder and neurasthenia (n=62: 30 Selank, 32 medazepam) | Not stated in the abstract | Not stated in the abstract | Anxiolytic effects of Selank and medazepam were similar on Hamilton, Zung and CGI scales, and Selank also showed anti-asthenic and psychostimulant effects. Serum leu-enkephalin half-life, low at baseline, rose during Selank treatment, mostly in patients with GAD. |
| Medvedev VE et al.2015 · Zh Nevrol Psikhiatr Im S S Korsakova · PMID 26356395 | Human, randomised controlled trial, anxiety disorders (n=70: 30 phenazepam alone, 40 Selank plus phenazepam) | Not stated in the abstract | Not stated in the abstract | Adding Selank brought on the effect of phenazepam earlier on the HDRS and reduced phenazepam side effects such as attention and memory impairment, sedation and asthenia, during treatment and after withdrawal. Quality of life on the SF-36 improved. |
| Medvedev VE et al.2014 · Zh Nevrol Psikhiatr Im S S Korsakova · PMID 25176261 | Human, comparative clinical trial versus phenazepam, phobic-anxiety and somatoform disorders (n=60) | Not stated in the abstract | Not stated in the abstract | The authors report a pronounced anxiolytic and mild nootropic effect of Selank, lasting a week after the last dose, and a positive effect on quality of life. |
| Panikratova YR et al.2020 · Dokl Biol Sci · PMID 32342318 | Human, placebo-controlled resting-state fMRI study in healthy participants (n=52, Selank, Semax or placebo) | Not stated in the abstract | Single administration; scans before and 5 and 20 min after | Differences were found in connectivity between the right amygdala and the right temporal cortex, with both general and specific effects of Selank and Semax. |
| Uchakina ON et al.2008 · Zh Nevrol Psikhiatr Im S S Korsakova · PMID 18577961 | Human, generalised anxiety disorder and neurasthenia, plus cell culture (patient peripheral blood) | 10⁻⁷ M in vitro; in-vivo dose not stated in the abstract | 14 days (in vivo) | In vitro, Selank completely suppressed IL-6 gene expression in blood cells from patients with depression but not healthy controls. In treated patients, the serum Th1/Th2 cytokine balance changed. |
| Sokolov OY et al.2002 · Bull Exp Biol Med · PMID 12432865 | Mouse (BALB/c and C57Bl/6), open-field test and plasma enzyme assay | 100 mcg/kg | Not stated in the abstract | Selank had an anxiolytic effect in the open-field test and lengthened plasma leu-enkephalin half-life in BALB/c mice, with no effect on behaviour or enkephalinase activity in C57Bl/6 mice. |
| Konstantinopolsky MA et al.2022 · Bull Exp Biol Med · PMID 36322304 | Rat (outbred), naloxone-precipitated morphine withdrawal model | 0.3 mg/kg, intraperitoneal (diazepam 2 mg/kg as comparator) | Single injection | Selank reduced the total morphine withdrawal index by 39.6% and raised the tactile sensitivity threshold 9-fold, slightly less than diazepam (49.3% and 13-fold). |
| Kolik LG et al.2019 · Bull Exp Biol Med · PMID 31625062 | Rat (outbred), 30 weeks of 10% ethanol as the only fluid; object recognition test | 0.3 mg/kg a day, intraperitoneal | 7 days | Selank prevented ethanol-induced memory and attention disturbances during withdrawal and prevented the ethanol-induced rise in BDNF in the hippocampus and frontal cortex. |
What these studies don't show: There are controlled trials, though they answer narrow questions. Who was enrolled, what was measured and for how long all constrain what the results mean. Results hold for the setting studied and no further. Testing establishes identity and purity; it is not evidence of an effect.
Every study links to its PubMed record. See all Selank studies in the research library →
Selank price in Canada: 10mg vial
Buy Selank in Canada in a 10mg vial, plus a nasal spray and a starter kit. Prices are in Canadian dollars, you pay by Interac e-Transfer or bank transfer, and orders are shipped from Canadian stock.
| Size | Price | Per mg |
|---|---|---|
| 10 mg | $52.00 | $5.20/mg |
Other formats and kits
Is Selank available in Canada?
Canada has no authorized Selank product: no DIN has been issued for it. Health Canada has made no finding about it, because it has never been submitted for one. Borealis Peptides holds it for in-vitro research; it is not supplied for use in any living subject. How Health Canada treats research peptides →
Side effects reported in studies
Each statement is tied to the study that reported it. Any tolerability finding below is quoted from the study that reported it. Human work of this size does not establish a safety profile. Read more →
Doses used in studies
Selank FAQ
What is Selank?
Selank is a synthetic tuftsin analogue (heptapeptide). The published work on it is in rat, human and mouse. Borealis Peptides supplies it as lyophilised powder in 10 mg vials and a ready-mixed nasal spray for in-vitro laboratory research. It is not authorized as a medicine and is not for use in any living subject. The table on this page gives each study, its model and its reported result.
Where can I buy Selank in Canada?
It ships within Canada from stock we hold, in 10 mg vials. Nothing leaves without HPLC confirmation of identity and purity for that batch. Borealis Peptides accepts research orders only, and ships to research and business addresses. Identity and purity are checked per batch, and the paperwork names that batch specifically.
Is Selank legal in Canada?
Canada has no authorized Selank product: no DIN has been issued for it. Health Canada has made no finding about it, because it has never been submitted for one. Borealis Peptides holds it for in-vitro research; it is not supplied for use in any living subject. Health Canada has said that "Research Use Only" labelling does not make a product legal to use in a person, so we treat it as a description of what the material is supplied for rather than a permission.
How much Selank should I use?
Borealis Peptides gives no dosing, protocols or reconstitution volumes, and will not provide them on request. In laboratory work the amount follows from the study design, which a supplier cannot sensibly set. The figures on this page are what specific published studies used in their own models: a record of what was done, not a recommendation.
What human evidence is there for Selank?
Of the 8 studies cited, 3 are controlled trials in people and the rest are animal or cell work. Each row names its model, the amount used and what the authors reported, so the weight of each study can be judged directly rather than through a summary.
Does Selank need refrigeration?
The dry powder sits at −20 °C, shielded from light. In solution it is kept at 2–8 °C. The lyophilised powder tolerates ambient temperature in transit, so it ships without ice and goes into the fridge on arrival. What degrades a lyophilised peptide is light and temperature cycling rather than transit time.
Does Selank need bacteriostatic water?
The nasal spray arrives as a finished solution in its own bottle, so nothing is added to it: no bacteriostatic water, no mixing, no transfer. Only the lyophilised vial is supplied dry, and that is the one format bacteriostatic water applies to. It is sold separately.
How is the purity of Selank confirmed?
Every batch is tested by HPLC before it is sold, and the certificate refers to the batch in your vial rather than to the product in general. Keeping that batch number with your records is what makes an observation reproducible later. Certificates are available on request.
How does Selank compare with Semax and DSIP?
Each has its own published record, and comparing them is a matter of reading both. Semax and DSIP have 8 cited studies and 8 cited studies on their page against 8 here. Set the two evidence tables side by side and the difference is visible directly.
Why is Selank named in a Health Canada advisory?
Because it was among the peptides seized from sellers offering unauthorized injectable products online. The advisory concerns material sold for people to inject without authorization. Borealis Peptides supplies research material for laboratory use and sells nothing for injection or for any use in a person, which is the line that advisory draws.
