- Also known as
- Epithalon · Epithalone · Epitalone · AEDG peptide · Ala-Glu-Asp-Gly
- Class
- Synthetic pineal tetrapeptide
- Form
- Lyophilised powder in 10 mg vials
- Sizes
- 10 mg
- Storage, dry
- −20 °C, dry and dark
- Storage, mixed
- 2–8 °C, use within 28 days of mixing (as generally reported for reconstituted peptides)
- BAC water per size
- 10 mg: 2 mL
What is Epitalon?
Suppliers and the literature both list Epitalon as a synthetic pineal tetrapeptide. Published work on it is in rat, human, cell culture and mouse oocytes. The name covers the same material written several ways in the literature, including Epithalon, Epithalone and Epitalone. Its sequence is recorded as Four amino acids: Ala-Glu-Asp-Gly (AEDG).. People have received it in 2 studies, none of them controlled, which means those results cannot separate the compound from everything else that changed. We hold it as lyophilised powder in 10 mg vials; it is research material and nothing else. Nothing here is a medicine; it is not for human or veterinary use.
What the research shows
| Study | Model | Dose used | Duration | Finding |
|---|---|---|---|---|
| Khavinson V et al.2002 · Neuro Endocrinol Lett · PMID 12195242 | Human, controlled clinical trial in patients with degenerative retinal lesions, with a Campbell rat model of inherited retinal degeneration; n not stated in the abstract | Not stated in the abstract | Not stated in the abstract | In rats, epitalon was associated with greater bioelectric and functional activity of the retina and preserved retinal structure. In patients, the authors report a positive clinical effect in 90% of cases. |
| Ivko OM et al.2020 · Adv Gerontol · PMID 33280326 | Human, middle-aged people with reduced pineal melatonin function; design and n not stated in the abstract | Not stated in the abstract | Not stated in the abstract | AEDG increased urinary 6-sulfatoxymelatonin excretion 1.7-fold, normalised raised Clock and Csnk1e gene expression in leukocytes (1.9–2.1-fold) and doubled low Cry2 expression in lymphocytes. |
| Khavinson VKh et al.2003 · Bull Exp Biol Med · PMID 12910293 | Rat, Campbell rats with inherited retinal degeneration | Not stated in the abstract | Given to offspring after birth, and to mothers before mating and during pregnancy | Retinal structure and function were preserved about twice as long as in control rats, and 30% longer than in rats given the peptide only after birth. |
| Vinogradova IA2009 · Adv Gerontol · PMID 20405731 | Rat, ageing study under different light regimes | Not stated in the abstract | Not stated in the abstract | Age-related changes in thyroid-related hormones appeared later in rats given melatonin or epitalon than in controls, and both smoothed seasonal variation in thyroid hormone levels under the natural light regime of north-west Russia. |
| Khavinson VKh et al.2003 · Bull Exp Biol Med · PMID 12937682 | Cell culture (telomerase-negative human fetal fibroblasts) | Not stated in the abstract | Not stated in the abstract | Adding epitalon induced expression of the catalytic subunit of telomerase, telomerase activity and telomere elongation. |
| Al-Dulaimi S et al.2025 · Biogerontology · PMID 40908429 | Cell culture (human breast cancer lines 21NT and BT474, normal epithelial cells and fibroblasts) | Not stated in the abstract (dose-dependent effect reported) | Not stated in the abstract | Telomere length increased with dose in normal cells through hTERT and telomerase upregulation. In the cancer cell lines, telomeres also lengthened, through ALT activation rather than telomerase. |
| Gatta M et al.2025 · Stem Cell Rev Rep · PMID 40493162 | Cell culture (human retinal pigment epithelial cells, ARPE-19, injured by high glucose) | Not stated in the abstract | Not stated in the abstract | Epitalon restored delayed wound closure in high-glucose-injured cells by inhibiting epithelial-mesenchymal transition and fibrosis-related changes. The authors say more work is needed to confirm benefits and safety. |
| Yue X et al.2022 · Aging (Albany NY) · PMID 35413689 | Mouse oocytes, in vitro post-ovulatory ageing model | 0.1 mM in culture medium | 6, 12 and 24 hours of culture | Epitalon reduced reactive oxygen species, lowered spindle defects and abnormal cortical granule distribution at 12 and 24 hours, raised mitochondrial membrane potential and reduced oocyte apoptosis by 24 hours. |
What these studies don't show: The human work here is uncontrolled: pilot studies, case reports and retrospective reviews. Any improvement recorded could have come from something else entirely. Small numbers and brief follow-up leave long-term safety untouched. A certificate of analysis answers what the material is, not what it does.
Every study links to its PubMed record. See all Epitalon studies in the research library →
Epitalon price in Canada: 10mg vial
Buy Epitalon (Epithalon) in Canada in a 10mg vial and a starter kit. Prices are in Canadian dollars, you pay by Interac e-Transfer or bank transfer, and orders are shipped from Canadian stock.
| Size | Price | Per mg |
|---|---|---|
| 10 mg | $42.50 | $4.25/mg |
Starter kit
Is Epitalon available in Canada?
No product containing Epitalon holds a Drug Identification Number in Canada. Health Canada has made no finding about it, because it has never been submitted for one. Borealis Peptides supplies it for in-vitro laboratory research only, not for human or veterinary use. How Health Canada treats research peptides →
Side effects reported in studies
The studies cited below report what they observed on tolerability, and those statements are reproduced as written. Human work of this size does not establish a safety profile.
Epitalon FAQ
What is Epitalon?
Epitalon is a synthetic pineal tetrapeptide. The published work on it is in rat, human, cell culture and mouse oocytes. Borealis Peptides supplies it as lyophilised powder in 10 mg vials for in-vitro laboratory research. It is not a drug, and it is not supplied for use in a person or an animal. Every reference here is listed with the model it ran in and the finding as published.
Where can I buy Epitalon in Canada?
Direct from Borealis Peptides, held in Canadian stock so nothing crosses a border on its way to you. Stocked in 10 mg vials. Purity is confirmed by HPLC batch by batch, and we supply for laboratory research only. Every batch is tested by HPLC and the certificate names the batch in your vial.
Is Epitalon legal in Canada?
No product containing Epitalon holds a Drug Identification Number in Canada. Health Canada has made no finding about it, because it has never been submitted for one. Borealis Peptides supplies it for in-vitro laboratory research only, not for human or veterinary use. Health Canada has said that "Research Use Only" labelling does not make a product legal to use in a person, so we treat it as a description of what the material is supplied for rather than a permission. Lawful use in your own setting is yours to establish.
How much Epitalon should I use?
Borealis Peptides gives no dosing, protocols or reconstitution volumes, and will not provide them on request. In laboratory work the amount follows from the study design, which a supplier cannot sensibly set. The figures on this page are what specific published studies used in their own models: a record of what was done, not a recommendation.
What human evidence is there for Epitalon?
There is human work, but none of it is controlled. 2 studies involved people, as pilots, case reports or retrospective reviews. Without a control group these cannot show that the compound caused what was observed, and the page says so beside the table.
What storage does Epitalon need?
The dry powder sits at −20 °C, shielded from light. In solution it is kept at 2–8 °C. The lyophilised powder tolerates ambient temperature in transit, so it ships without ice and goes into the fridge on arrival. What degrades a lyophilised peptide is light and temperature cycling rather than transit time.
How is the purity of Epitalon confirmed?
Every batch is tested by HPLC before it is sold, and the certificate refers to the batch in your vial rather than to the product in general. Keeping that batch number with your records is what makes an observation reproducible later. Certificates are available on request.
How does Epitalon compare with Thymosin Alpha-1 and MOTS-C?
These are separate compounds with separate literatures; no ranking is offered here. Thymosin Alpha-1 and MOTS-C have 5 cited studies and 7 cited studies on their page against 8 here. Set the two evidence tables side by side and the difference is visible directly.
Why is Epitalon named in a Health Canada advisory?
Because it was among the peptides seized from sellers offering unauthorized injectable products online. The advisory concerns material sold for people to inject without authorization. Borealis Peptides supplies research material for laboratory use and sells nothing for injection or for any use in a person, which is the line that advisory draws.
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