- Also known as
- Semax Selank blend · Selank + Semax · Semax/Selank 20 mg
- Class
- Two-peptide research blend (ACTH(4-10) analogue + tuftsin analogue)
- Form
- Lyophilised powder in 20 mg vials
- Sizes
- 20 mg
- Storage, dry
- −20 °C, dry and dark
- Storage, mixed
- 2–8 °C, use within 28 days of mixing (as generally reported for reconstituted peptides)
- BAC water per size
- 20 mg: 3 mL
What is Semax + Selank?
Semax + Selank is a single vial holding Semax 10 mg and Selank 10 mg as one lyophilised powder. The two are studied separately in the literature, and the studies cited on this page are those separate studies. Its sequence is recorded as Semax 10 mg (Met-Glu-His-Phe-Pro-Gly-Pro) and Selank 10 mg (Thr-Lys-Pro-Arg-Pro-Gly-Pro); both end in Pro-Gly-Pro. Published work on it is in human, mouse and enzyme assay in vitro. 4 of the 8 studies listed below are controlled trials in people. Supplied as lyophilised powder in 20 mg vials, held in Canadian stock, for laboratory research. Nothing here is a medicine; it is not for human or veterinary use.
What the research shows
| Study | Model | Dose used | Duration | Finding |
|---|---|---|---|---|
| Gusev EI et al.2018 · Zh Nevrol Psikhiatr Im S S Korsakova · PMID 29798983 | Human, controlled clinical study, ischaemic stroke rehabilitation (n=110) | 6000 mcg/day | Two 10-day courses with a 20-day interval | Semax raised plasma BDNF, which stayed high through the study, regardless of when rehabilitation started. Semax and high BDNF were associated with faster improvement and a better final Barthel index score. |
| Gusev EI et al.1997 · Zh Nevrol Psikhiatr Im S S Korsakova · PMID 11517472 | Human, controlled clinical trial, acute hemispheric ischaemic stroke (n=30 Semax, 80 conventional-therapy controls) | 12 mg/day (moderate stroke) and 18 mg/day (severe stroke) were reported as the most effective daily doses | 5- and 10-day courses | Adding Semax to standard intensive therapy had some influence on the rate of recovery of neurological function, particularly motor deficits, assessed with clinical scales, EEG mapping and somatosensory evoked potentials. |
| Lebedeva IS et al.2018 · Bull Exp Biol Med · PMID 30225715 | Human, placebo-controlled resting-state fMRI study in healthy volunteers (n=24: 14 Semax, 10 placebo) | Intranasal 1% Semax (volume not stated in the abstract) | Single administration; scans before and 5 and 20 min after | The Semax group showed a greater volume of the rostral (medial frontal cortex) subcomponent of the default mode network than the placebo group. |
| Zozulia AA et al.2008 · Zh Nevrol Psikhiatr Im S S Korsakova · PMID 18454096 | Human, randomised controlled trial, generalised anxiety disorder and neurasthenia (n=62: 30 Selank, 32 medazepam) | Not stated in the abstract | Not stated in the abstract | Anxiolytic effects of Selank and medazepam were similar on Hamilton, Zung and CGI scales, and Selank also showed anti-asthenic and psychostimulant effects. Serum leu-enkephalin half-life, low at baseline, rose during Selank treatment, mostly in patients with GAD. |
| Medvedev VE et al.2015 · Zh Nevrol Psikhiatr Im S S Korsakova · PMID 26356395 | Human, randomised controlled trial, anxiety disorders (n=70: 30 phenazepam alone, 40 Selank plus phenazepam) | Not stated in the abstract | Not stated in the abstract | Adding Selank brought on the effect of phenazepam earlier on the HDRS and reduced phenazepam side effects such as attention and memory impairment, sedation and asthenia. Quality of life on the SF-36 improved. |
| Panikratova YR et al.2020 · Dokl Biol Sci · PMID 32342318 | Human, placebo-controlled resting-state fMRI study in healthy participants (n=52); separate Semax, Selank and placebo groups | Not stated in the abstract | Single administration; scans before and 5 and 20 min after | Differences were found in connectivity between the right amygdala and the right temporal cortex, with both general and specific effects of Selank and Semax. Each participant received one peptide or placebo, not both. |
| Kost NV et al.2001 · Bioorg Khim · PMID 11443939 | Enzyme assay in vitro (enkephalin-degrading enzymes from human serum); Semax and Selank tested separately | Dose-dependent; IC50 10 µM for Semax and 20 µM for Selank | Not applicable (enzyme assay) | Both heptapeptides inhibited the enkephalin-degrading enzymes of human serum more strongly than puromycin (IC50 10 mM) and bacitracin. Their pentapeptide fragments also inhibited the enzymes; tri-, tetra- and hexapeptide fragments did not. |
| Sokolov OY et al.2002 · Bull Exp Biol Med · PMID 12432865 | Mouse (BALB/c and C57Bl/6), open-field test and plasma enzyme assay | 100 mcg/kg | Not stated in the abstract | Selank had an anxiolytic effect in the open-field test and lengthened plasma leu-enkephalin half-life in BALB/c mice, with no effect on behaviour or enkephalinase activity in C57Bl/6 mice. |
What these studies don't show: Controlled human data exists, but it is limited in scope. Selected groups and surrogate endpoints limit how far these findings reach. Safety beyond those trial conditions remains unestablished. Knowing the vial holds what the label says is not the same as knowing the compound does anything.
Every study links to its PubMed record. See all Semax + Selank studies in the research library →
Semax + Selank price in Canada: 20mg vial
Buy Semax + Selank in Canada in a 20mg vial. Prices are in Canadian dollars, you pay by Interac e-Transfer or bank transfer, and orders are shipped from Canadian stock.
| Size | Price | Per mg |
|---|---|---|
| 20 mg | $95.00 | $4.75/mg |
Is Semax + Selank available in Canada?
Canada has no authorized Semax + Selank product: no DIN has been issued for it. Health Canada has made no finding about it, because it has never been submitted for one. Borealis Peptides holds it for in-vitro research; it is not supplied for use in any living subject. How Health Canada treats research peptides →
Side effects reported in studies
Each statement is tied to the study that reported it. Tolerability observations from the cited papers appear below in the authors own terms. Human work of this size does not establish a safety profile.
Semax + Selank FAQ
What is Semax + Selank?
Semax + Selank is a two-peptide research blend (ACTH(4-10) analogue + tuftsin analogue). The published work on it is in human, mouse and enzyme assay in vitro. Borealis Peptides supplies it as lyophilised powder in 20 mg vials for in-vitro laboratory research. Nothing here is a medicine; it is not for human or veterinary use. The table on this page gives each study, its model and its reported result.
Where can I buy Semax + Selank in Canada?
It ships within Canada from stock we hold, in 20 mg vials. Nothing leaves without HPLC confirmation of identity and purity for that batch. Borealis Peptides accepts research orders only, and ships to research and business addresses. Identity and purity are checked per batch, and the paperwork names that batch specifically.
Is Semax + Selank legal in Canada?
Canada has no authorized Semax + Selank product: no DIN has been issued for it. Health Canada has made no finding about it, because it has never been submitted for one. Borealis Peptides holds it for in-vitro research; it is not supplied for use in any living subject. Health Canada has said that "Research Use Only" labelling does not make a product legal to use in a person, so we treat it as a description of what the material is supplied for rather than a permission.
How much Semax + Selank should I use?
There is none to give. Nothing on this site is a protocol, a schedule or a reconstitution volume. The amounts in the cited studies belong to those studies and to the models they ran in, and they are listed so the evidence can be weighed rather than taken on trust.
What human evidence is there for Semax + Selank?
Of the 8 studies cited, 4 are controlled trials in people and the rest are animal or cell work. Each row names its model, the amount used and what the authors reported, so the weight of each study can be judged directly rather than through a summary.
Does Semax + Selank need refrigeration?
Unopened, keep it at −20 °C in the dark. In solution it is kept at 2–8 °C. Because the dry form is stable at room temperature, shipping needs no cold chain; refrigerate it when it arrives. What degrades a lyophilised peptide is light and temperature cycling rather than transit time.
How is the purity of Semax + Selank confirmed?
Every batch is tested by HPLC before it is sold, and the certificate refers to the batch in your vial rather than to the product in general. Keeping that batch number with your records is what makes an observation reproducible later. Certificates are available on request.
How does Semax + Selank compare with Semax and Selank?
Each has its own published record, and comparing them is a matter of reading both. Semax and Selank have 8 cited studies and 8 cited studies on their page against 8 here. Set the two evidence tables side by side and the difference is visible directly.
Why is Semax + Selank named in a Health Canada advisory?
Because it was among the peptides seized from sellers offering unauthorized injectable products online. The advisory concerns material sold for people to inject without authorization. Borealis Peptides supplies research material for laboratory use and sells nothing for injection or for any use in a person, which is the line that advisory draws.
